凯发_Vincent Bouchiat

Speaker-Vincent Bouchiat

Vincent Bouchiat
Neel Institute at National Center of Scientific Research (CNRS-Grenoble)

Vincent Bouchiat is a director of research at Neel Institute at National Center of Scientific Research (CNRS-Grenoble) in France. He received his education at the School of Physics and Chemistry of Paris and at the University Pierre & Marie Curie. He then prepared his phD in the Quantronics Group of CEA-Saclay on the study of Quantum Coherence in superconducting devices. In 1997, He was appointed as a permanent research fellow at CNRS at the University of Marseilles where he proposed new methods of miniaturizing quantum devices and SQUIDs using Scanning Probe Microscopy and carbon nanostructures. He moved to the low temperature lab of Grenoble in 2000 where efforts were directed towards the interfacing of molecular devices and Graphene with superconducting electrodes. He is currently orienting his research on biomedical applications of 2D materials. He was a visiting professor at Miller Institute at the Physics department of UC Berkeley during the academic years 2007-2008. He co-authored more than 70 peer-reviewed papers and hold 7 patents.

Title：

SymposiumHealth Care

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Abstract

"Graphenebandages as a wound-healing platform”

Vincent BOUCHIAT

Neel Institute CNRS Grenoble

Abstract:

We are developing a technology platformthat exploits the features of graphene, an atomically-thin layer of pure carbonfor its promising perspectives in biomedical applications. Indeed, Graphene has well-known and outstanding heat- andelectro-conductive properties, but it is also providing a biostimulatinginterface useful for tissue engineering. I will present also the perspectivefor both academic and industrial developments of this technology. Thefirst-generation of our system is a graphene-based scaffold that looks like avery thin, transparent plaster. I willshow results of in-vitro cellular growth(1) (neurons and fibroblast) ongraphene-covered substrates which show that growth of cells is promoted by thegraphene substrate (2) we can also detect the electric activity of cells downto the single ion limit.

Basedon that material, we are building an innovative bandage technology platformbased on graphene-on -insulator film in order to better support chronic wounds.Chronic wounds are serious health issues that are currently becoming a majorhumanistic and economic burden due to the augmentation of the population ofelderly and diabetics. Chronic wounds indeed lead to nearly 500,000 amputationseach year worldwide and are globally generating direct and indirect costs(stays in hospital) totaling 12 billion € globally. Therefore, there is anurgent need for novel therapies. monolayer graphene film with its biostimulating effect (1) is providing the ideal technology to unlock thechallenges for a better induce cells regrowthand promote tissue engineering with minimal release of nanoflakes.

Our bandage platform (3) is based on the integration ofa monolayer graphene polycrystalline layer back-bonded onto a biocompatiblepolymer layer. The resulting film can directly be applied onto the bed-woundand is inserted in a commercial bandage. Graphene surface combineshealing (speed-up of wound closure) and antibacterial action, opticaltransparency and electrical conductivity. It is obtained by integrating a largeuniform graphene monolayer into a bandage in order to provide a bio-stimulatingand electrically-active platform directly applied in contact with the wound. Itallows the development of a range of intelligent dressings that combine on thesame product both therapeutic and diagnostic actions.. The graphene coveredbandages show clear enhancement of cellular growth together with in situdetection of the electrical activity. The specific properties of graphene makeit a substrate useful for providing wound dressing enabling a novel woundhealing technology

-Therapeuticbecause graphene functions as a growth matrix, promoting healing but at thesame time acting as an electrode in close contact with the wound. This allowsthe application of electrical pulses whose actions promote faster healing andreduce pain.

-Diagnosticbecause it plays at the same time the role of an embedded remote measurementphysical parameters used to monitor the wound evolution and early stagedetection of infection.

Themarkets of the connected dressing with the remote diagnosis will be addressedin a second phase.

[1] F.Veliev et al. 2D Materials (2018)

[2] F.Veliev et al. Biomat. 86, 33-41, (2016)

[3] www.grapheal.com